… iodide [47, 48], most likely acts as a Cl-/I- anion exchanger in … significantly interfere
with pendrin activity. The fluorescence … : Fast fluorometric method for measuring pendrin (SLC26A4) …

… variants was assessed by measurement of their ion transport activities using a fluorometric
method and determination of the … Fast fluorometric method for measuring pendrin (SLC26A4) …

… interventions aimed at restoring the transport activity of dysfunctional pendrin variants. …
functionally affected and unaffected variants and assessing possible correlations between (a) …

… , ie, measurement of the ion transport activity by a fluorometric … transport activity of pendrin
was determined by measuring … Cl − /HCO 3 − and Cl − /I − exchange activity, localized at the …

… Pendrin (SLC26A4) is an anion exchanger expressed in the … to cause a loss of Cl − /I −
exchange activity 34 and P142R … After titration, we selected the Cl − /I − concentration tuning the …

… measured in cells expressing wild type pendrin and significantly higher than that measured
in control cells, indicating that the ion transport … The transport activity of pendrin p.M21V was …

… modifiers of pendrin activity and on SLC26A4 gene sequence … flux, measurement of
intracellular pH, measurement of … 50 % inhibition of pendrin transport activity in the low micromolar …

… in the PDS/SLC26A4 gene cause the Pendred syndrome, an … above, the cells were quickly
washed with warm PBS. … synthesis and activity is inhibited, while pendrin [Pendred syndrome (…

… Cl - , and a rapid intracellular acidification occurred after the … of CFTR and much less
SLC26A4 (pendrin). As reported, … Cl - /HCO 3 - exchange activity was measured fluorometrically …

… After the periods of exposure described above, the cells were quickly washed with … pendrin
synthesis, since we 243 have observed that iodide excess treatment augmented Pds/Slc26a4 …